sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Fas mediated apoptosis could be detected by 5 h by increase in the number of Annexin V positive cells compared with 3.7+/- 0.7% in the untreated cells. Fas mediated apoptosis corelated with cellular acidification. Fas ligation failed to signal apoptosis when acidification was inhibited by pH clamping with nigericin. Additionaly Fas signaled acidification and apoptosis was SHP-1 dependent. In cells overexpressing SHP-1 the number of apoptotic cells was 2-fold higher compared with untransfected control cells. Fas ligation decreased the pHi of SHP-1 overexpressing cells to 6.3 +/- 0.06 compared with 6.45 +/- 0.07 in untransfected cells. Further an increase in membrane-associated tyrosine phosphatase activity concomitant with a decrease in the cytosolic enzyme activity was seen in Fas-ligated cells. Such redistribution of the enzyme activity paralleled Fas-mediated induction of membrane translocation of SHP-1." ;
    prov:wasQuotedFrom pubmed:10506221 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10506221 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}