. . . . . . . "[We propose the following cascade for protein arginine methyltransferase 5 (PRMT5)-mediated neuronal death: amyloid beta (A?) deposition decreases PRMT5 expression in neurons, which increases E2F-1 expression - a PRMT5 target protein - and subsequently activates GSK-3? and NF-?B to induce caspase-3-dependent neuronal apoptosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:12:07+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .