sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.4" .
  sub:_5 prov:value "MTF-1 is absolutely essential for upregulation of MT-I gene expression in visceral endoderm cells and that optimal expression also involves interactions of the basic helix-loop-helix upstream stimulatory factor-1 (USF1) with an E-box1-containing sequence at -223 bp in the MT-I promoter. Metal ion regulation of MT expression is mediated by metal response elements (MREs). MRE-binding transcription factor-1 (MTF-1), a six zinc-finger protein of the Cys2His2 family, binds directly and specifically to MREs (Westin and Schaffner, 1988; Radtke et al., 1993; Koizumi et al., 1999) and regulates metal-induced and basal MT expression in cultured cells (Heuchel et al., 1994)." ;
    prov:wasQuotedFrom pubmed:11230134 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11230134 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}