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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#_5 http://www.w3.org/ns/prov#value We studied the effects of protein kinase C (PKC) and tyrosine kinase on the expression of CTGF and observed that at the mRNA level CTGF expression is inhibited by the activation of PKC, but stimulated by the inhibition of PKC and tyrosine kinase. We further determined that the novel and the classical PKC isoforms are needed for the inhibition, but the atypical isoforms are not involved. Our data suggest that phosphorylation on serine/threonine and tyrosine by PKC and by tyrosine kinase are all inhibitory to the expression of CTGF. http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10964664 http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10964664 http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#_5 http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U#pubinfo http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U http://purl.org/dc/terms/created 2014-07-03T14:29:52.178+02:00 http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA-N_okLoCuTuzPyBkhc7icuT28Mk9neThLYCwFSV49-U http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234