http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#head http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#assertion http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#provenance http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#assertion http://rdf.disgenet.org/resource/gda/DGNf691c04bc81195e96fc1f00d82cca968 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/10966 http://rdf.disgenet.org/resource/gda/DGNf691c04bc81195e96fc1f00d82cca968 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0006142 http://rdf.disgenet.org/resource/gda/DGNf691c04bc81195e96fc1f00d82cca968 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#provenance http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#assertion http://purl.org/dc/terms/description [Five lines of evidence suggest that melatonin works via epigenetic processes: (1) melatonin influences transcriptional activity of nuclear receptors (ERalpha, GR and RAR) involved in the regulation of breast cancer cell growth; (2) melatonin down-regulates the expression of genes responsible for the local synthesis or activation of estrogens including aromatase, an effect which may be mediated by methylation of the CYP19 gene or deacetylation of CYP19 histones; (3) melatonin inhibits telomerase activity and expression induced by either natural estrogens or xenoestrogens; (4) melatonin modulates the cell cycle through the inhibition of cyclin D1 expression; (5) melatonin influences circadian rhythm disturbances dependent on alterations of the light/dark cycle (i.e., light at night) with the subsequent deregulation of PER2 which acts as a tumor suppressor gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/18592373 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v5.0.0/void/BEFREE http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v5.0.0/void/BEFREE http://purl.org/pav/importedOn 2017-02-19 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/dc/terms/created 2017-10-17T13:18:04+02:00 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v5.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP1235700.RA-qcJRGp9bHcJmRmq9i2XWAvw3lK7POEkWfkSVKgXNC8 http://purl.org/pav/version v5.0.0.0 http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v5.0.0