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bp(GO:"response to oxidative stress") =| phos(p(HGNC:PTPN1))
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Approximately 61,000 statements.
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Treatment of PTP1B with diamide and reduced glutathione or with only glutathione disulfide (GSSG) results in a modification detected by mass spectrometry in which the cysteine residues are oxidized to mixed disulfides with glutathione. The activity is recovered by the addition of dithiothreitol, presumably by reducing the cysteine disulfides.
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Selventa
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