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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#_4 http://www.w3.org/ns/prov#value To determine the in vivo role of cellular glutathione peroxidase (E.C.1.11.1.9, GPX1), we challenged the GPX1 knockout [GPX1(-/-)], the GPX1 overexpressing [GPX1(+)], and their respective wild-type (WT) mice of different Se and vitamin E status with acute oxidative stress. After these mice were injected with pro-oxidants paraquat or diquat at 12 to 125 mg/kg of body weight, their survival rate and time were a function of their GPX1 activity levels. The GPX1 protection was associated with attenuation of NADPH and NADH oxidation, protein carbonyl and F(2)-isoprostanes formation, and alanine transaminase release in various tissues, and was irreplaceable by high levels of dietary vitamin E or other selenoproteins. The GPX1 expression was also protective against moderate oxidative stress induced by low levels of paraquat or diquat, particularly in the Se-deficient mice. Alteration of GPX1 expression showed no impact on the expression of other selenoproteins and antioxidant enzymes in unstressed mice. Total Se content in liver of the Se-adequate GPX1(-/-) mice was reduced by 60% the WT controls. In conclusion, normal expression of GPX1 is essential and overexpression of GPX1 is beneficial to protect mice against acute oxidative stress. http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11568445 http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11568445 http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#_4 http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ http://purl.org/dc/terms/created 2014-07-03T14:29:58.279+02:00 http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA1D9E5KiEG8RDZn5AV0psxGQcfW8WeEp092fBQDsHTrQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234