. . . . . . . . . . . . . . . . . "p(HGNC:IL18BP) -> (p(HGNC:IL1B) -> a(SCHEM:Dinoprostone))" . "p(HGNC:IL1B) -> a(SCHEM:Dinoprostone)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "IL-18 binding protein (IL-18BP) is a naturally occurring and specific inhibitor of IL-18. When recombinant IL-18BP was added to PBMC cultures, unexpectedly, spontaneous PGE(2) production increased. PGE(2) production was also increased by the addition of IL-18BP to PBMC stimulated with either IL-1beta or IL-12 and also in whole blood cultures stimulated with Staphylococcus epidermidis. These studies demonstrate that IL-18BP decreases endogenous IL-18 activity by reducing IFN-gamma-mediated responses." . . "Selventa" . . . . "2014-07-03T14:29:50.084+02:00"^^ . . .