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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#_5 http://www.w3.org/ns/prov#value IL-18 binding protein (IL-18BP) is a naturally occurring and specific inhibitor of IL-18. When recombinant IL-18BP was added to PBMC cultures, unexpectedly, spontaneous PGE(2) production increased. PGE(2) production was also increased by the addition of IL-18BP to PBMC stimulated with either IL-1beta or IL-12 and also in whole blood cultures stimulated with Staphylococcus epidermidis. These studies demonstrate that IL-18BP decreases endogenous IL-18 activity by reducing IFN-gamma-mediated responses. http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10681439 http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10681439 http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#_5 http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs#pubinfo http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs http://purl.org/dc/terms/created 2014-07-03T14:29:50.084+02:00 http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA1_Nd0nDt2Ks9Ejzdyu_jj0h4b64X13cmvHDfdK4IRgs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234