. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "complex(p(HGNC:PRKCZ),p(HGNC:RAF1),p(HGNC:YWHAB)) -> (kin(p(HGNC:PRKCZ)) => p(HGNC:RAF1,pmod(P)))" . "kin(p(HGNC:PRKCZ)) => p(HGNC:RAF1,pmod(P))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Together, the results suggest that 14-3-3 binds both PKC-zeta (at phospho-Ser-186) and Raf-1 in a ternary complex. Phosphorylation of 14-3-3beta by PKC-zeta negatively regulated their physical association. 14-3-3beta with its putative PKC-zeta phosphorylation sites mutated enhanced co-precipitation between PKC-zeta and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-zeta weakens the complex in vivo. We conclude that 14-3-3 facilitates coupling of PKC-zeta to Raf-1 in an isotype-specific and phosphorylation-dependent manner. We suggest that 14-3-3 is a transient mediator of Raf-1 phosphorylation and activation by PKC-zeta." . . "Selventa" . . . . "2014-07-03T14:29:49.580+02:00"^^ . . .