. . . . . . . "[At ?6 mo of age, double-mutant mice develop amyloid pathology, with signs of neuritic dystrophy, intracellular A? accumulation, and glial inflammation, an increase in A?PP C-terminal fragments, and an 8 times increase in A?42 levels with a 40% decrease in A?40 levels, leading to a significant increase (14 times) of A?42/A?40 ratios, with minimal effects on presenilin or the Notch1 pathway in the brain.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:15:03+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .