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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#_4 http://www.w3.org/ns/prov#value The nuclear factor of activated T cells (NFAT) family of transcription factors regulates the development and differentiation of several tissue types. Here, we examine the role of NFATC2 in skeletal muscle by analyzing adult NFATC2(-/)- mice. These mice exhibit reduced muscle size due to a decrease in myofiber cross-sectional area, suggesting that growth is blunted. Muscle growth was examined during regeneration after injury, wherein NFATC2-null myofibers form normally but display impaired growth. The growth defect is intrinsic to muscle cells, since the lack of NFATC2 in primary muscle cultures results in reduced cell size and myonuclear number in myotubes. Retroviral-mediated expression of NFATC2 in the mutant cells rescues this cellular phenotype. Myonuclear number is similarly decreased in NFATC2(-/)- mice. Taken together, these results implicate a novel role for NFATC2 in skeletal muscle growth. We demonstrate that during growth of multinucleated muscle cells, myoblasts initially fuse to form myotubes with a limited number of nuclei and that subsequent nuclear addition and increases in myotube size are controlled by a molecular pathway regulated by NFATC2. http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11309414 http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11309414 http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#_4 http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4#pubinfo http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4 http://purl.org/dc/terms/created 2014-07-03T14:29:55.617+02:00 http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA2QFxaCQCrQ4jkDQW_KrBU-czF9kUK6XS9PFiP0AtE_4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234