sub:provenance { beldoc:dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ; dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ; dce:title "BEL Framework Small Corpus Document" ; dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ; pav:authoredBysub:_7 ; pav:version "1.6" . sub:_6prov:value """Importantly, it has been demonstrated that hypoxia promotes tumour cell invasion by inducing the expression of the Met receptor [54]. This establishes a mechanism whereby transformed cells can be spurred to exit a hypoxic microenvironment and invade the surrounding tissues, which provide more favourable growth conditions. Because HIF-1a is involved in Met gene expression, the constitutive activation of HIF-1a as a consequence of pVHL deregulation provides a mechanism explaining the observation that the expression of HGF and Met receptor is associated with genetic alterations of VHL in primary RCC.""" ; prov:wasQuotedFrompubmed:15350900 . sub:_7rdfs:comment "support@belframework.org" ; rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:15350900 ; prov:wasDerivedFrombeldoc: , sub:_6 . }