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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#_3 http://www.w3.org/ns/prov#value However, the effect of IL-18 on basal proliferation, as examined in our study, was not explored. This group also found that murine, not human, IL-18 suppressed FGF-2-induced corneal neovascularization in mice, although the IL-18 was administered by i.p. injections, and it is unclear whether local rather than systemic treatment would have induced divergent results. Interestingly, they also found that IL-18 suppressed angiogenesis in the chick chorioallantoic membrane model. Our finding that IL-18 did not induce HMVEC proliferation is consistent with results obtained for other angiogenic mediators, such as soluble VCAM-1 or soluble E-selectin, which also do not induce endothelial proliferation (14). Consistent with the chemotactic properties of IL-18, we also showed IL-18 induction of HMVEC tube formation in Matrigel matrix in vitro. The degree of tube formation by IL-18 at 1 nM was comparable with the stimulant PMA (50 mM), a potent inducer of HMVEC differentiation and tube formation (51). In the Matrigel in vivo mouse angiogenesis model, IL-18 also stimulated actual blood vessel formation, which was visibly in excess of control. http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11466388 http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11466388 http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#_3 http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w#pubinfo http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w http://purl.org/dc/terms/created 2014-07-03T14:29:57.521+02:00 http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA4hsO6cHp2PIUyHdjrea2eAzpQ9YbnbTNL42bdaC3S-w http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234