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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#_7 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#_6 http://www.w3.org/ns/prov#value We next asked whether components of the JNK cascade could directly promote human epidermal neoplasia. We expressed either active MKK7 or c-Jun in primary keratinocytes and examined their capacity to promote tumorigenesis in combination with Ras in the absence of IκBα. First, we confirmed induction of AP1-dependent gene reporter activity by MKK7 in vitro (Supplementary Fig. S4). Surface skin grafts were then regenerated with primary keratinocytes expressing MKK7 and Ras; these developed into clinical tumors resembling SCC (Fig. 3A). Dermal invasion, one of the hallmarks of spontaneous human SCC, is apparent in tumors induced by MKK7 and Ras as revealed by both histologic appearance and BMZ disruption (Fig. 3B–C). MKK7 and Ras-induced neoplasia depends on intact AP1 function as concurrent expression of DNc-Jun prevents tumorigenesis (Fig. 3A–C). http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17440097 http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#_7 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17440097 http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#_6 http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4#pubinfo http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4 http://purl.org/dc/terms/created 2014-07-03T14:29:32.897+02:00 http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA4yDD8xXWd0HRsVhWnKxVf-ahQ16DuRDC5YeRqNyFXu4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234