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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#_4 http://www.w3.org/ns/prov#value Insulin pretreatment for 8, 16, 20, 24 hours resulted in reduction of bGH- induced phosphorylated Stat5B. Maximal inhibition (25-30% of control) was observed at all times between 12 and 24 hours pretreatment with insulin. Moreover Insulin pretreatment for 16 hours also significantly inhibited bGH induced Jak2 tyrosine phosphorylation. These results demonstrate that Growth hormone stimulated Jak2/Stat5B phosphorylation was inhibited by chronic insulin treatment and Jak2 mediates STA5B phosphorylation. http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10224108 http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10224108 http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#_4 http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0#pubinfo http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0 http://purl.org/dc/terms/created 2014-07-03T14:29:47.001+02:00 http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA5KMNPFma0MhrV3eGZ7hHgBI6KI4T3WDzJnBTIalOyB0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234