. . . . . . . "[� Twenty-seven probes in 9 genes showed significant differential methylation and expression (P<5.5x10-4).� The top gene was protein tyrosine phosphatase, non-receptor type 22 (PTPN22), which was hypermethylated (delta beta range: +15.4 to +16.0%) and underexpressed (log 2 gene expression intensity: bicuspid 5.1 vs. trileaflet 7.9, P=2x10-5) in bicuspid patients, as compared to tricuspid patients.� Numerous genes involved in cardiovascular development were also differentially methylated, but not differentially expressed, including ACTA2 (4 probes, delta beta range:� -10.0 to -22.9%), which when mutated causes the syndrome of familial thoracic aortic aneurysms and dissections]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:10:15+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .