http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#Head http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#assertion http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#provenance http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#pubinfo http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_3 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4617 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_2 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/serum%20insulin http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D009130 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D017667 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_4 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_1 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"serum insulin") -| kin(p(HGNC:GSK3B)) http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#assertion http://www.w3.org/2000/01/rdf-schema#label kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> (a(SCHEM:"serum insulin") -| kin(p(HGNC:GSK3B))) http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_6 http://www.w3.org/ns/prov#value Inhibition of PI3-kinase activity using a dominant negative mutant (30), or pharmacological agents such as wortmannin or LY294002 (31), abolishes insulin stimulated glucose uptake and inhibits GLUT4 vesicle translocation to the plasma membrane. Many other cellular effects of insulin, such as antilipolysis, activation of fatty acid synthesis, acetyl CoA-carboxylase, glycogen synthase, Akt phosphorylation, glycogen synthase kinase 3b inactivation, and stimulation of protein synthesis and DNA synthesis, are also inhibited by PI3- kinase suppression PIP3, rather than PIP2, is the major mediator of PI3- kinase dependent biological actions of insulin http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10194465 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10194465 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#_6 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE#pubinfo http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE http://purl.org/dc/terms/created 2014-07-03T14:29:46.513+02:00 http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA5hF8LrW8oWFpSlOs-p9vGcjN3MSiwaGVY8CTzphHptE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234