. . . . . . . . . . "complex(p(HGNC:CREB1),g(HGNC:LDLR))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "SIRE (Sterol-independent regulatory element, -17 to -1) is the LDLR promoter region which overlaps the TATA-like element and consists of a C/EBP binding site and a functional cAMP responsive element (CRE). Three DNA-protein complexes (C1, C3 and C4) were detected in control extracts and 4 complexes (C1, C2, C3 and C4) were detected in oncostatin M-treated nuclear extracts using a P32-labeled oligonucleotide probe (TATA1+2) containing LDLR promoter sequence -25 to +5. EMSA studies demonstrated that the C3 complex in both control and OM-treated extracts was completely supershifted by anti-CREB1 antibodies. The results suggest that the transcription factor cAMP-responsive element binding protein (CREB-1) binds to the SIRE region of LDLR and C3 is composed of homodimers or heterodimers of the CREB family." . . "Selventa" . . . . "2014-07-03T14:29:49.969+02:00"^^ . . .