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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA5mkKVNNwuAZI8V5fB-liwEYApvJUK99aYnpNq9bbwd4#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA5mkKVNNwuAZI8V5fB-liwEYApvJUK99aYnpNq9bbwd4#_3 http://www.w3.org/ns/prov#value SIRE (Sterol-independent regulatory element, -17 to -1) is the LDLR promoter region which overlaps the TATA-like element and consists of a C/EBP binding site and a functional cAMP responsive element (CRE). Three DNA-protein complexes (C1, C3 and C4) were detected in control extracts and 4 complexes (C1, C2, C3 and C4) were detected in oncostatin M-treated nuclear extracts using a P32-labeled oligonucleotide probe (TATA1+2) containing LDLR promoter sequence -25 to +5. EMSA studies demonstrated that the C3 complex in both control and OM-treated extracts was completely supershifted by anti-CREB1 antibodies. 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