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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#_5 http://www.w3.org/ns/prov#value Two classes of differentiation factors, the neurotrophins and fibroblast growth factors, induce rapid tyrosine phosphorylation of SNT1(FRS2alpha), which in turn enables SNT1 to recruit Shp2 tyrosine phosphatase and Grb2 adaptor protein in complex with the Ras GDP/GTP exchange factor Sos. Mutagenesis of SNT1(IRS)CX identified three classes of effector motifs within SNT critical for both sustained ERK activation and neuronal differentiation: 1) four phosphotyrosine motifs that mediate recruitment of Grb2, 2) two phosphotyrosine motifs that mediate recruitment of Shp2, and 3) a C-terminal motif that functions by helping to recruit Sos. http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11278583 http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11278583 http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#_5 http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U#pubinfo http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U http://purl.org/dc/terms/created 2014-07-03T14:29:55.010+02:00 http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA5xfrl-_tULBrzBdQsZIRTHU28k1EnnaKxL2ng0L4S3U http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234