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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#_2 http://www.w3.org/ns/prov#value The relative contributions of superoxide anion (O2-) and peroxynitrite (PN) were evaluated in the pathogenesis of intestinal microvascular damage caused by the intravenous injection of E. coli lipopolysaccharide (LPS) in rats. The intravenous injection of LPS elicited an inflammatory response that was characterized by a time-dependent infiltration of neutrophils, lipid peroxidation, microvascular leakage (indicative of microvascular damage), and epithelial cell injury in both the duodenum and jejunum. Administration of the SODm SC-55858, FeTMPS or FeTMPyP at 3 h post LPS reduced the subsequent increase in microvascular leakage, lipid peroxidation and epithelial cell injury.% Our results suggest that O2 and peroxynitrite play a significant role in the pathogenesis of duodenal and intestinal injury during endotoxaemia and that their remoyal by SODm and peroxynitrite decomposition catalysts offers a novel approach to the treatment of septic shock or clinical conditions of gastrointestinal inflammation. http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10401559 http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10401559 http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#_2 http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE#pubinfo http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE http://purl.org/dc/terms/created 2014-07-03T14:29:47.630+02:00 http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA7CHQtPu3XjTDBxT3jsLeExPncqEI_OHC2Nc2GeUfQXE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234