. . . . . . . "[Our data support the view that PS1 mutations lead to a strong ?-secretase loss-of-function phenotype and an increased A?1-42/A?1-40 ratio, two mechanisms that are potentially involved in the pathogenesis of Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:15:42+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .