. . . . . . . . . . . . . . . . . . "p(PFH:\"TGFB Family\") -> complex(p(HGNC:SMAD7),p(HGNC:SMURF1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "The Smurfs can also regulate ubiquitination and degradation of other target proteins, including the TGF-b receptor complex and the transcriptional co-repressor SnoN (Bonni et al., 2001; Ebisawa et al., 2001; Kavsak et al., 2000; Stroschein et al., 2001) (Fig. 7). Smurf1 and Smurf2 associate with the nuclear I-Smad Smad7 after stimulation by TGF-b (Ebisawa et al., 2001; Kavsak et al., 2000). The I-Smad-Smurf complex is exported to the cytoplasm and ubiquitinates the receptors on the cell surface or endosomal membranes; these are then targeted for degradation in proteasomes and lysosomes." . . "Selventa" . . . . "2014-07-03T14:30:00.364+02:00"^^ . . .