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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA7rA-U0Vtx9MwxoG7ZwIDpfHnMnt8pYTuUatX0wgc3CM#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA7rA-U0Vtx9MwxoG7ZwIDpfHnMnt8pYTuUatX0wgc3CM#_6 http://www.w3.org/ns/prov#value The Smurfs can also regulate ubiquitination and degradation of other target proteins, including the TGF-b receptor complex and the transcriptional co-repressor SnoN (Bonni et al., 2001; Ebisawa et al., 2001; Kavsak et al., 2000; Stroschein et al., 2001) (Fig. 7). Smurf1 and Smurf2 associate with the nuclear I-Smad Smad7 after stimulation by TGF-b (Ebisawa et al., 2001; Kavsak et al., 2000). 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