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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#_8 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#_7 http://www.w3.org/ns/prov#value Localization of GTP-bound Ras to the inner surface of the cell membrane activates several downstream effectors, most notably the serine/threonine kinase Raf, which is the first signaling element in the MAPK pathway. 2,67,68 As shown in Figure 1, other downstream effectors of Ras include the PI3K cell survival pathway, the small GTP-binding proteins Rac and Rho, and the stress-activated protein kinase pathway (also referred to as the c-jun N-terminal kinase [JNK] pathway). 69-71 In addition, in response to cellular stress and cytokine stimulation mediated through Ras, the dual-specificity p38MAPK kinases (MKK3 and MKK6) and the JNK kinases (MKK4 and MKK7) phosphorylate p38MAPK and JNK, respectively. 72-76 http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16170185 http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#_8 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16170185 http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#_7 http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E#pubinfo http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E http://purl.org/dc/terms/created 2014-07-03T14:29:30.384+02:00 http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA8mzp6KOSyL4a2c-pMSmndq1VCLD55_G0X6Tp5SKDH3E http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234