@prefix dc: .
@prefix this: .
@prefix sub: .
@prefix beldoc: .
@prefix rdfs: .
@prefix rdf: .
@prefix xsd: .
@prefix dce: .
@prefix pav: .
@prefix np: .
@prefix belv: .
@prefix prov: .
@prefix chebi: .
@prefix RNA: .
@prefix mgi: .
@prefix geneProductOf: .
@prefix species: .
@prefix occursIn: .
@prefix orcid: .
sub:Head {
this: np:hasAssertion sub:assertion;
np:hasProvenance sub:provenance;
np:hasPublicationInfo sub:pubinfo;
a np:Nanopublication .
}
sub:assertion {
sub:_1 geneProductOf: mgi:106091;
a RNA: .
sub:_2 occursIn: species:10090;
rdf:object sub:_1;
rdf:predicate belv:increases;
rdf:subject chebi:41564;
a rdf:Statement .
sub:assertion rdfs:label "a(CHEBI:cholesterol) -> r(MGI:Cyp7a1)" .
}
sub:provenance {
beldoc: dce:description "Approximately 61,000 statements.";
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
dce:title "BEL Framework Large Corpus Document";
pav:authoredBy sub:_5;
pav:version "1.4" .
sub:_3 dce:identifier "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16";
dce:title "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16";
dce:type "Book" .
sub:_4 prov:value "Page 442 Feeding rats with a cholesterol-enriched diet induces bile acid synthesis. This increase is attributable to the rise in cyp7a activity, which catalyzes the rate-limiting step of the classical pathway. Interrupting the return of bile acids to the liver, by diverting bile or by feeding a bile acid-binding resin, also stimulates the synthesis of bile acids. In contrast, reintroduction of bile acids into bile-diverted rats reverses the stimulatory effect, indicating that bile acid synthesis is subject to end-product inhibition. It was later discovered that cyp7a enzyme activity is closely correlated with cyp7a mRNA abundance, indicating that cyp7a gene transcription is the major determinant of cyp7a activity.";
prov:wasQuotedFrom sub:_3 .
sub:_5 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource sub:_3;
prov:wasDerivedFrom beldoc:, sub:_4 .
}
sub:pubinfo {
this: dc:created "2014-07-03T14:29:44.572+02:00"^^xsd:dateTime;
pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}