sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_6 ; pav:version "1.4" . sub:_4dce:identifier "Entrez Gene summary HNMT Human" ; dce:title "Entrez Gene summary HNMT Human" ; dce:type "Online Resource" . sub:_5prov:value "Entrez Gene summary: Human: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene." ; prov:wasQuotedFromsub:_4 . sub:_6rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcesub:_4 ; prov:wasDerivedFrombeldoc: , sub:_5 . }