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[The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known regarding the effects of CPT on hypoxia-inducible factor-2? (HIF-2?) accumulation and activity in clear cell renal cell carcinoma (ccRCC).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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