. . . . . . . "[Previous studies have demonstrated that chronic brain hypoperfusion (CBH) causes A? aggregation by upregulating expression of amyloid precursor protein (APP) and ?-site APP cleaving enzyme 1 (BACE1) protein, which is accompanied by cognitive impairment, but the mechanisms are not fully understood.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:10:38+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .