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[HDAC2 appears to mediate the action of steroids to switch off activated inflammatory genes, but in patients with COPD, patients with severe asthma, and smokers with asthma, HDAC2 activity and expression are reduced by oxidative stress through activation of phosphoinositide 3-kinase ?.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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