@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RALg4jr1hCvhR9N7uzAeV4OnRh280a0qIlnqMF0ZopDPc> .
@prefix sub: <http://purl.org/np/RALg4jr1hCvhR9N7uzAeV4OnRh280a0qIlnqMF0ZopDPc#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0013600> biolink:category biolink:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0013600>;
    rdf:predicate biolink:treats;
    rdf:subject <https://go.drugbank.com/drugs/DB00980>;
    a rdf:Statement;
    rdfs:label "Ramelteon is a synthetic melatonin receptor agonist with high affinity for the MT1 and MT2 receptors, and is approved by the FDA for use in adults. Only few case reports have been published in children with NDDs reporting in general limited efficacy on night awakenings";
    biolink:association_type biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:cohort;
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/28921528/>;
    biolink:relation nkg:OffLabelIndication .
  
  sub:cohort rdfs:label "Children";
    biolink:category biolink:Cohort;
    biolink:has_phenotype <http://purl.obolibrary.org/obo/MONDO_0100038> .
  
  <https://go.drugbank.com/drugs/DB00980> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "JgxMRWedTOozzP8ZSOKUKZqbwJjQmjkbhdk/7KNBz524L2GvPFt2UPqhcePuduTeF5H1JrSKNPtVZ/NWGdddtTgv/wIGlERUo78wFHbLHqmJYxPdmZe7IYcQydUFle6k7x0IcV24+ttS8vIx+gtZi3kX6DBto+dLN/Kw7KIMDaY=";
    npx:hasSignatureTarget this: .
  
  this: dcterms:created "2021-05-19T20:26:01.809+02:00"^^xsd:dateTime;
    dcterms:creator orcid:0000-0002-7641-6446;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAZdZj78B6nKrP1Q00oFzsK07u7WdiY3sToz-H-H2nSgg> .
}