@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RAM8XybF7aWxN3kCWJ91nyMTYChDOz0LPKkrzXUNltsUk> .
@prefix sub: <http://purl.org/np/RAM8XybF7aWxN3kCWJ91nyMTYChDOz0LPKkrzXUNltsUk#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/HP_0000713> biolink:category biolink:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/HP_0000713>;
    rdf:predicate biolink:treats;
    rdf:subject <https://go.drugbank.com/drugs/DB01043>;
    a rdf:Statement;
    rdfs:label "Nonpharmacological interventions are suggested as first-line treatment, but aren't effective for every patient, resulting in pharmacological interventions for some patients, consisting of off-label use of antipsychotics, sedative/hypnotics, anxiolytics, acetylcholinesterase inhibitors, memantine, and antidepressants; where efficacy doesn't necessarily outweigh associated risks.";
    biolink:association_type biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:cohort;
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/28300462/>;
    biolink:relation nkg:OffLabelIndication .
  
  sub:cohort rdfs:label "Elderly";
    biolink:category biolink:Cohort;
    biolink:has_phenotype <http://purl.obolibrary.org/obo/MONDO_0004975> .
  
  <https://go.drugbank.com/drugs/DB01043> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "SFsrVpqT11LZ5z8Bj2dU6Vt7FuUHzfFHrKQmCauXbFF9QBt3FRkadcApxY83Qdg3RD9Nb15ywuELS1NB/HryuGrWnqqvUZtS8wXSL4crbH7XvP3ZwpN3JRq7og6YTynCNU+rwDDPdhHqMe2li2joRVEHSeTsybsDjcbfDTuCCd8=";
    npx:hasSignatureTarget this: .
  
  this: dcterms:created "2021-05-28T17:19:55.499+02:00"^^xsd:dateTime;
    dcterms:creator orcid:0000-0002-7641-6446;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}