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[A multi-targeted ALK/ROS1/MET inhibitor, crizotinib, targeting this activated tyrosine kinase has led to significant clinical benefit including tumor shrinkage and prolonged survival without disease progression and has been approved by US FDA since 2011 for the treatment of advanced ALK-rearranged NSCLC (Ou et al.Oncologist 17:1351-1375, 2012).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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