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[The associated region extends 120 kb encompassing 11 candidate genes.While AGER encodes a key receptor for amyloid-? protein, an analysis of network context based upon genes now confirmed to contribute to dementia risk (A?PP, PSEN1, PSEN2, CR1, CLU, PICALM, and APOE) suggested strong functional coupling to NOTCH4, with no significant coupling to the remaining candidates.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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