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[The most popular current hypothesis is that Alzheimer's disease (AD) is caused by aggregates of the amyloid peptide (Abeta), which is generated by cleavage of the Abeta protein precursor (APP) by beta-secretase (BACE-1) followed by gamma-secretase.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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