sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_6 ; pav:version "1.4" . sub:_5prov:value "Several growth factors, most notably insulin-like growth factor-2 (IGF2) and transforming growth factor-a (TGF-a), are also HIF-1 target genes. Binding of these factors to their cognate receptors the insulin-like growth factor 1 receptor (IGF1R) and epidermal growth-factor receptor (EGFR), respectively activates signal-transduction pathways that lead both to HIF-1a expression (as described above) and to cell proliferation survival. HIF-1 therefore contributes to autocrine-signalling pathways that are crucial for cancer progression (FIG. 6)." ; prov:wasQuotedFrompubmed:13130303 . sub:_6rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:13130303 ; prov:wasDerivedFrombeldoc: , sub:_5 . }