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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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hepatic nuclear factor 3 (HNF3) and nuclear factor 1 (NF1) are necessary for an appropriate expression of the ALAS gene. Insulin overrides the HNF3beta or HNF3beta plus NF1-mediated stimulation of ALAS transcriptional activity. Electrophoretic mobility shift assay and Southwestern blotting indicate that HNF3 binds to the ALAS promoter We propose a model in which insulin exerts its negative effect through the disturbance of HNF3beta binding or transactivation potential
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Selventa
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2014-07-03T14:30:23.172+02:00
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