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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#_5 http://www.w3.org/ns/prov#value Genetic analysis reveals that IRAK is required for IL-1-induced activation of TAK1. We show that IL-1 stimulation induces the rapid but transient association of IRAK, TRAF6, TAB2, and TAK1. TAB2 is recruited to this complex following translocation from the membrane to the cytosol upon IL-1 stimulation. In IRAK-deficient cells, TAB2 translocation and its association with TRAF6 are abolished. These results suggest that IRAK regulates the redistribution of TAB2 upon IL-1 stimulation and facilitates the formation of a TRAF6-TAB2-TAK1 complex. http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11259596 http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11259596 http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#_5 http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY http://purl.org/dc/terms/created 2014-07-03T14:29:54.761+02:00 http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAQ9YE5DHn_e3-3Fd2pu79Y-rALKVyLl-o1s960vhmzuY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234