http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#Head http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#assertion http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#provenance http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#assertion http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11345 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D008168 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_1 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=46024 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:"trichostatin A") -> r(HGNC:RECK) http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_3 http://www.w3.org/ns/prov#value Histone deacetylase (HDAC) inhibitors are known toexert antimetastatic and antiangiogenic activity in vitro and in vivo. RECK is a membrane-anchored glycoprotein that negatively regulates matrixmetalloproteinases (MMPs) and inhibits tumor metastasis and angiogenesis. Inthis study, we test the possibility that HDAC inhibitor may increase RECKexpression to inhibit MMP activation and cancer cell invasion. Our resultsshowed that trichostatin A (TSA) up-regulated RECK via transcriptionalactivation in CL-1 human lung cancer cells. Flow cytometric analysisdemonstrated that RECK protein on cell surface was increased after treatment ofTSA. Moreover, up-regulation of RECK expression by TSA attenuated MMP-2activity. To explore whether HDAC inhibitor-induced inhibition of MMP-2activation is indeed mediated via RECK, we used small interference RNA (siRNA)to block RECK expression and found that inhibition of RECK by siRNA abolishedthe inhibitory effect of TSA on MMP-2 activation. In addition, TSA suppressedthe invasive ability of CL-1 cells. Taken together, this study reveals a novelmechanism by which HDAC inhibitors suppress tumor invasion and provides a newstrategy for cancer therapy. http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12810630 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12810630 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#_3 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o http://purl.org/dc/terms/created 2014-07-03T14:30:13.601+02:00 http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAQEkKv3CMQuAvFWkEV9pW721_WvMyIM4lfrcpxQvQ90o http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234