@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAQSbnYLRVJpHRb7iAZZtyadF1yR58HtYS19qSXGOV3bM> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAQSbnYLRVJpHRb7iAZZtyadF1yR58HtYS19qSXGOV3bM#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 geneProductOf: hgnc:12687 ;
    a Protein: .
  sub:_2 geneProductOf: hgnc:12680 ;
    a Protein: .
  sub:_3 occursIn: mesh:D007668 , species:9606 ;
    rdf:object sub:_2 ;
    rdf:predicate belv:decreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "p(HGNC:VHL) -| p(HGNC:VEGFA)" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Furthermore, the re-introduction of a degradation-resistant mutant of HIF-2a into RCC cells ectopically expressing pVHL abolishes the ability of VHL to suppress the growth of these cell lines [21]. VHL AS A MULTI-FACETED TUMOUR SUPPRESSOR Enhanced cell proliferation Several polypeptide growth factors that stimulate the proliferation of normal cells have pathological consequences for tumourigenesis when deregulated. RCC cells lacking functional pVHL overexpress various growth factors, including platelet-derived growth factor b (PDGFb), VEGF and transforming growth factor (TGF)-a [25]." ;
    prov:wasQuotedFrom pubmed:15350900 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15350900 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:30:27.335+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}