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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQSbnYLRVJpHRb7iAZZtyadF1yR58HtYS19qSXGOV3bM#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAQSbnYLRVJpHRb7iAZZtyadF1yR58HtYS19qSXGOV3bM#_4 http://www.w3.org/ns/prov#value Furthermore, the re-introduction of a degradation-resistant mutant of HIF-2a into RCC cells ectopically expressing pVHL abolishes the ability of VHL to suppress the growth of these cell lines [21]. VHL AS A MULTI-FACETED TUMOUR SUPPRESSOR Enhanced cell proliferation Several polypeptide growth factors that stimulate the proliferation of normal cells have pathological consequences for tumourigenesis when deregulated. 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