@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAQhg0Rso8ds38Pc2l0Fw_J8JR3TJkJtz_zsk2xOZdO6s> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAQhg0Rso8ds38Pc2l0Fw_J8JR3TJkJtz_zsk2xOZdO6s#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix rgd: <http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 geneProductOf: rgd:2582 ;
    a Protein: .
  sub:_2 occursIn: species:10116 ;
    rdf:object sub:_1 ;
    rdf:predicate belv:increases ;
    rdf:subject chebi:23965 ;
    a rdf:Statement .
  sub:assertion rdfs:label "a(CHEBI:estradiol) -> p(RGD:Esr2)" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "1.4" .
  sub:_3 prov:value "Estradiol interacting with its cognate receptor reduces the accumulation of Nos2 in rat smooth muscle cell. This effect might be due to the activation of either estrogen receptor alpha or estrogen receptor beta. Treating the cell  with Tamoxifen and ICI182,780 (antagonist of estrogen receptor)  blocks the estradiol induced decrease of Nos2 protein content." ;
    prov:wasQuotedFrom pubmed:10218948 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10218948 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:29:46.957+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}