http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#Head http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#assertion http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#provenance http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#assertion http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_1 http://www.selventa.com/vocabulary/variantOf http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3772 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_1 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/serum%20leptin http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"serum leptin") -> p(RGD:Stat3,pmod(P)) http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_3 http://www.w3.org/ns/prov#value In trh promoter assays using transfected cells, functional STAT3 proteins are required for maximal activation of the trh promoter by leptin. Consistent with this, the STAT3-binding site on the leptin receptor is also required for this regulation. Using double immunohistochemistry, we show that peripherally administered leptin rapidly stimulates STAT3 phosphorylation in approximately 40% of TRH neurons in the paraventricular nucleus of the hypothalamus (PVN) in rats. Detailed anatomical analyses reveal that the leptin-responsive TRH neurons are concentrated in the caudal region of the medial and periventricular parvocellular subnucleus of the PVN. Combined, our data show that only a subpopulation of TRH neurons in the PVN is leptin responsive and suggest that stimulation of hypothalamic trh gene expression by leptin involves activation of STAT3 and that this signaling pathway is important for regulation of the hypothalamic-pituitary-thyroid axis by leptin. http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14764629 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14764629 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#_3 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc http://purl.org/dc/terms/created 2014-07-03T14:30:20.322+02:00 http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAQtYDo5NaHsCD00_BXVWwi8GrMfhcKQtYFBAG7FbaOZc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234