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Approximately 61,000 statements.
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When Notch-IC is present, however, it competes with the inhibitory proteins to bind to CSL. Notch1-IC also directly stimulates expression of the cell-cycle regulator Waf1 (also known as Cip1 and p21) in primary mouse keratinocytes25. The increase in Waf1 concentration causes proliferating keratinocytes to withdraw from the cell cycle and helps to initiate terminal differentiation.
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