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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#_5 http://www.w3.org/ns/prov#value We demonstrated here that long-term tamoxifen treatment causes G2/M cell cycle arrest through c-jun N-terminal kinase (JNK) activation, which is dependent on phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine in an oestrogen (ER) receptor-positive breast cancer cell line, MCF-7. We conclude that JNK-mediated phosphorylation of FADD plays an important role in the negative regulation of cell growth and metastasis, independent of the ER status of a breast cancer, so that JNK/FADD signals might be promising targets for cancer therapy. http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16450001 http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16450001 http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#_5 http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4#pubinfo http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4 http://purl.org/dc/terms/created 2014-07-03T14:30:41.342+02:00 http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARCaf44TPcjjJCEsT95P5X6PBf2EXlRmmZTqKLA2bUo4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234