http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#Head http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#assertion http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#provenance http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#pubinfo http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#assertion http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_2 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1201674 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_3 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_4 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:97275 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_3 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_1 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#assertion http://www.w3.org/2000/01/rdf-schema#label tscript(p(MGI:Smad3)) -| tscript(p(MGI:Myod1)) http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_6 http://www.w3.org/ns/prov#value Transforming growth factor-beta (TGF-beta) is a potent inhibitor of skeletal muscle differentiation, but the molecular mechanism and signaling events that lead to this inhibition are poorly characterized. Here we show that the TGF-beta intracellular effector Smad3, but not Smad2, mediates the inhibition of myogenic differentiation in MyoD-expressing C3H10T1/2 cells and C2C12 myoblasts by repressing the activity of the MyoD family of transcriptional factors. Central to the induction of myogenic differentiation is the function of the MyoD family of basic helix-loop-helix (bHLH) transcription factors, which include MyoD, myogenin, Myf5, and MRF4 and are collectively referred to as myogenic regulatory factors or MRFs http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11711431 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11711431 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#_6 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw#pubinfo http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw http://purl.org/dc/terms/created 2014-07-03T14:29:59.146+02:00 http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARPkCUkHqek2l2_K7KU5C-Z25c9RkptnBXj1ggO36LNw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234