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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#_4 http://www.w3.org/ns/prov#value Here we demonstrate that association of YB-1 with the capped 5' terminus of the mRNA is regulated via phosphorylation by the serine/threonine protein kinase Akt. In contrast to its nonphosphorylated form, phosphorylated YB-1 fails to inhibit cap-dependent but not internal ribosome entry site-dependent translation of a reporter mRNA in vitro. Using Affymetrix microarrays, we found that many of the YB-1-associated messages encode stress- and growth-related proteins, raising the intriguing possibility that Akt-mediated YB-1 phosphorylation could, in part, increase production of proteins regulating cell proliferation, oncogenic transformation, and stress response. http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16354698 http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16354698 http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#_4 http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I#pubinfo http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I http://purl.org/dc/terms/created 2014-07-03T14:30:40.089+02:00 http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARQzyhF33XpQeMFMb33dFIHobW3Rg0hrryA2e7HFX24I http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234