http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#Head http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#assertion http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#provenance http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#assertion http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_2 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_2 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-rat-protein-families/Mapk%20JNK%20Family http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_3 http://purl.obolibrary.org/obo/RO_0002204 http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=61849 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D009130 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_3 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_1 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(PFR:"Mapk JNK Family")) -> r(RGD:Psma6) http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_5 http://www.w3.org/ns/prov#value Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta with high mortality. Although nonsurgical treatment for AAA is much awaited, few options are available because its molecular pathogenesis remains elusive. Here, we identify JNK as a proximal signaling molecule in the pathogenesis of AAA. Human AAA tissue showed a high level of phosphorylated JNK. We show that JNK programs a gene expression pattern in different cell types that cooperatively enhances the degradation of the extracellular matrix while suppressing biosynthetic enzymes of the extracellular matrix. Selective inhibition of JNK in vivo not only prevented the development of AAA but also caused regression of established AAA in two mouse models. Thus, JNK promotes abnormal extracellular matrix metabolism in the tissue of AAA and may represent a therapeutic target. http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16311603 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16311603 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#_5 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ http://purl.org/dc/terms/created 2014-07-03T14:30:39.800+02:00 http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAR_nkHsOw8EpPWsJzPUst02-K8RrUWEBjBW8pjEEgyTQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234