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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#_6 http://www.w3.org/ns/prov#value On the other hand, chemical FAS inhibitors as well as RNA interference-mediated silencing of FAS gene repress Her-2/neu gene expression at the transcriptional level. Moreover, specific FAS blockade synergistically sensitizes breast cancer cells carrying Her-2/neu-oncogene amplification and/or overexpression to trastuzumab-induced cell growth inhibition and apoptotic cell death. Strikingly, FAS inhibition synergistically interacts with trastuzumab in Her-2/neu-negative breast cancer cells engineered to overexpress Her-2/neu, thus suggesting that the molecular linkage between FAS activity and functioning of Her-2/neu cannot be explained only on the basis of a transcriptional repression of Her-2/neu gene promoter. http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15780499 http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15780499 http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#_6 http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI#pubinfo http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI http://purl.org/dc/terms/created 2014-07-03T14:30:33.555+02:00 http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARgfyV2JO9NYfoe8TFPaYMZ9h1-aHNTe_8CAD0h-UjuI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234